Go to PubMed and sign in with your NCBI account.
Beneath the search box, click Create alert.
Select No to not receive emailed notifications about your search. Click Save.
To access your saved searches, click the box with your username and select Dashboard.
Your saved searches will be near the top.
To remove or change a saved search, click Manage my Searches.
Click the cog next to the search you want to change.
You can edit or delete the search.
You can also save searches to your NCBI account from other NCBI databases like PubMed Central and NCBI Bookshelf.